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私たちは小動物の行動測定機器を開発、製造しています。

論文紹介


FDM 商品ページはこちら


FDM-300(マウス)
1Matsumoto E, Ishihara A, Tamai S, Nemoto A, Iwase K, Hiwasa T, Shibata S and Takiguchi M J Biol. Chem. 2010;285(43):33028-33036. Time-of-day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver.
2Oike H, Nagai K, Fukushima T, Ishida N and Kobori M Biochem. Biophys. Res. Com. 2010;402(1):7-13. High-salt diet advances molecular circadian rhythms in mouse peripheral tissues.
FDM-700A(ラット)
3Shobo M, Yamada H, Mihara T, Kondo Y, Irie M, Harada K, Ni K, Matsuoka N and Kayama Y Behav. Brain Res. 2011;216(2):561-568. Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: Validation with olanzapine and ziprasidone.

ペレットフィーダーユニット 商品ページはこちら

1 Satoh Y, Ishizuka K and Murakami T. J. Oral Biosci. 2008;50(3):200-206. Effects of lesions of the red nucleus on feeding and drinking in rats.

ドリンクセンサー 商品ページはこちら

1 Satoh Y, Ishizuka K and Murakami T. J. Oral Biosci. 2008;50(3):200-206. Effects of lesions of the red nucleus on feeding and drinking in rats.

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　＊　Yamamoto K, Asano K, Matsukawa N, Imaizumi M and Yamatodani A.
　　　Journal of Pharmacological and Toxicological Methods 2011;63(1):30-34.
　　　Time-course analysis of pica in rats using an automatic feeding monitoring system.

locomo 商品ページはこちら

1 Shim S and Tanaka H. Physiol Behav. 2000;71(5):477-83. Effects of restricted food access on circadian fluctuation of serotonin N-acetyltransferase activities in hereditary microphthalmic rats.
2Masuki S, Todo T, Nakano Y, Okamura H and Nose H. J. Physiol. 2005;566(1):213-224. Reduced α-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock.
3Niimi K, Takahashi E and Itakura C. Experimental Gerontology 2008;43(9):847-852. Improved short-term memory and increased expression of NR2B observed in senescence-accelerated mouse (SAM) P6.
4Niimi K, Takahashi E and Itakura C. Physiol Behav. 2009;96(3):464-469. Analysis of motor function and dopamine systems of SAMP6 mouse
5Masuki S and Nose H. J. Physiol. 2009;587(23):5783-5794. Increased cerebral activity suppresses baroreflex control of heart rate in freely moving mice.
6Niimi K, Takahashi E, and Itakura C. Brain Res. 2009;1250(23):175-182. Age dependence of motor activity and sensitivity to dopamine receptor 1 agonist, SKF82958, of inbred AKR/J, BALB/c, C57BL/6J, SAMR1, and SAMP6 strains.
7Niimi K and Takahashi E. Neurosci. Lett. 2009;458(2):53-56. Combination of modified SHIRPA and pharmacological approach uncovers neuronal alteration in senescence-accelerated mouse prone 6 (SAMP6) strain.
8Nakamura T, Tanaka S, Hirooka K, Toyoshima T, Kawai N, Tamiya T, Shiraga F, Tokuda M, Keep RF, Itano T and Miyamoto O. Neurosci. Lett. 2011;487(1,3):103-106. Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat.

回転カゴ 商品ページはこちら

1Sujino M et al. Current Biology 2003:13:664-668. Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrythmic mice.
2Sujino M et al. European J. Neruoscience 2007:26:2731-2738. Temporal profile of circadian clock gene expression in a transplanted suprachiasmatic nucleus and peripheral tissues.
(上記論文に使用されている回転かごは現在販売中のものとサイズが異なっておりますので、御注意ください。)

パッシブアボイダンス 商品ページはこちら


1Yoshiyuki Soeda Y, Tsuneki H, Muranaka H, Mori N, Hosoh S, Ichihara Y, Kagawa S, Wang Xu, Toyooka N, Takamura Y, Uwano T, Nishijo H, Wada T and Sasaoka T. Molecular Endocrinology 2010:24(10):1965-1977. The Inositol Phosphatase SHIP2 Negatively Regulates Insulin/IGF-I Actions Implicated in Neuroprotection and Memory Function in Mouse Brain.

コミュニケーションボックス 商品ページはこちら

  • Uehara T, Sumiyoshi T, Itoh H, Kurachi M. Psychopharmacology (Berl). 2007 Dec;195(2):297-302.
    Role of glutamate transporters in the modulation of stress-induced lactate metabolism in the rat brain.
  • Uehara T, Sumiyoshi T, Matsuoka T, Itoh H, Kurachi M. Psychopharmacology (Berl). 2006 Jun;186(2):218-25.
    Role of 5-HT(1A) receptors in the modulation of stress-induced lactate metabolism in the medial prefrontal cortex and basolateral amygdala.
  • Uehara T, Sumiyoshi T, Itoh H, Kurachi M. Brain Res. 2003 Oct 31;989(1):112-6.
    Modulation of stress-induced dopamine release by excitotoxic damage of the entorhinal cortex in the rat.

    • 小動物握力測定装置 商品ページはこちら

    1 Akio Satow, Shunsuke Maehara, Satoko Ise, Hirohiko Hikichi, Miyuki Fukushima, Gentaroh Suzuki, Toshifumi Kimura, Takeshi Tanaka, Satoru Ito, Hiroshi Kawamoto, and Hisashi Ohta. J. Pharmacol. Exp. Ther. 2008;326:577-86. Pharmacological Effects of the Metabotropic Glutamate Receptor 1 Antagonist Compared with Those of the Metabotropic Glutamate Receptor 5 Antagonist and Metabotropic Glutamate Receptor 2/3 Agonist in Rodents: Detailed Investigations with a Selective Allosteric Metabotropic Glutamate Receptor 1 Antagonist, FTIDC [4-[1-(2-Fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide].

    前肢機能測定用階段試験装置 商品ページはこちら

    1Lee JK, Kim JE, Sivula M, Strittmatter SM. J Neurosci. 2004 Jul 7; 24(27):6209-17. Nogo receptor antagonism promotes stroke recovery by enhancing axonal plasticity.
    2 Baird AL, Meldrum A, Dunnett SB. Brain Res Bull. 2001 Jan 15; 54(2):243-50. The staircase test of skilled reaching in mice.
    3Biernaskie J, Corbett D. J Neurosci. 2001 July 15; 21(14):5272-80 Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury.

    動物用自動注入ポンプ(シリンジポンプ) 商品ページはこちら

    1Kobayashi M, Kiyono Y, Maruyama R, Mori T, Kawai K and Okazawa H. Journal of Cerebral Blood Flow & Metabolism, (28 July 2010) doi:10.1038/jcbfm.2010.122 Development of an H215O steady-state method combining a bolus and slow increasing injection with a multiprogramming syringe pump. (本文献中のFP-2000はFP-2100の旧型機です。)

    SCANET 商品ページはこちら

    1 M. Shinozaki, Y. Takahashi, M. Mukaino, N. Saito, Y. Toyama, H Okano and M. Nakamura. J. Biomed. Biotechnol. 2011;2011:157458. Abstract
    Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice.
    2 M. Shobo, Y. Kondo, H. Yamada, T. Mihara, N. Yamamoto, M. Katsuoka, K. Harada, K. Ni, and N. Matsuoka J. Pharmacol. Exp. Ther., Jun 2010; 333: 772 - 781. Abstract
    Norzotepine, a Major Metabolite of Zotepine, Exerts Atypical Antipsychotic-Like and Antidepressant-Like Actions through Its Potent Inhibition of Norepinephrine Reuptake
    3 Yoshitake Sano, Veravej G. Ornthanalai, Kazuyuki Yamada, Chihiro Homma, Hitomi Suzuki, Toshiharu Suzuki, Niall P. Murphy, and Shigeyoshi Itohara J. Neurosci., May 2009; 29: 5884 - 5896. Abstract
    X11-Like Protein Deficiency Is Associated with Impaired Conflict Resolution in Mice
    4 Katsuya Morita, Naoyo Motoyama, Tomoya Kitayama, Norimitsu Morioka, Koki Kifune, and Toshihiro Dohi J. Pharmacol. Exp. Ther., Aug 2008; 326: 633 - 645. Abstract
    Spinal Antiallodynia Action of Glycine Transporter Inhibitors in Neuropathic Pain Models in Mice
    5 Hironao Nakayama, Kiyoyuki Kitaichi, Yukiko Ito, Katsunori Hashimoto, Kenji Takagi, Toyoharu Yokoi, Kenzo Takagi, Norio Ozaki, Tuneyuki Yamamoto et al. Brain Res., Dec 2007; 1184: 260 - 269. Abstract
    The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats
    6 Norimasa Taniguchi and Shigeyuki Kanai Evid. Based Complement. Altern. Med., Mar 2007; 4: 99 - 105. Abstract
    Efficacy of Static Magnetic Field for Locomotor Activity of Experimental Osteopenia
    7 Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yasutomo Ito, Yukihiro Noda, Taku Nagai, and Toshitaka Nabeshima J. Neurosci., Jul 2007; 27: 7604 - 7615. Abstract
    A Novel Molecule "Shati" Is Involved in Methamphetamine-Induced Hyperlocomotion, Sensitization, and Conditioned Place Preference
    8 Takafumi Shirakawa, Kenji Nakano, Naomi S. Hachiya, Nobumasa Kato, Kiyotoshi Kaneko Neurosci Res,2007; 59: 117-23.
    Temporospatial patterns of COX-2 expression and pyramidal cell degeneration in the rat hippocampus after trimethyltin administration.
    9 A Matsumoto, Y Okada, M Nakamichi, M Nakamura, Y Toyama, G Sobue, M Nagai, M Aoki, Y Itoyama, and H Okano J Neurosci Res, Jan 2006; 83(1): 119-33. Abstract
    Disease progression of human SOD1 (G93A) transgenic ALS model rats.
    10 Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda, and Toshitaka Nabeshima J. Pharmacol. Exp. Ther., Apr 2006; 317: 334 - 340. Abstract
    Inhibition of Neprilysin by Infusion of Thiorphan into the Hippocampus Causes an Accumulation of Amyloid b and Impairment of Learning and Memory
    11 Y Yamaguchi, H Miyashita, H Tsunekawa, A Mouri, H-C Kim, K Saito, T Matsuno, S Kawashima, and T Nabeshima J. Pharmacol. Exp. Ther., Jun 2006; 317: 1079 - 1087. Abstract
    Effects of a Novel Cognitive Enhancer, Spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446), on Learning Impairments Induced by Amyloid-b1–40 in the Rat
    12 Kiyoyuki Kitaichi, , Masaya Fukuda, Hironao Nakayama, Nagisa Aoyama, Yukiko Ito, Yohei Fujimoto, Kenji Takagi, Kenzo Takagi and Takaaki Hasegawa Neurosci. Lett., July 2005; 382: 195 - 200. Abstract
    Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice
    13 Takatoshi Murase, Satoshi Haramizu, Akira Shimotoyodome, Azumi Nagasawa, and Ichiro Tokimitsu Am J Physiol Regulatory Integrative Comp Physiol, Mar 2005; 288: R708 - R715. Abstract
    Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice
    14 Yoshiaki Miyamoto, Ling Chen, Masahiro Sato, Masahiro Sokabe, Toshitaka Nabeshima, Tony Pawson, Ryuichi Sakai, and Nozomu Mori J. Neurosci., Feb 2005; 25: 1826 - 1835. Abstract
    Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC/N-Shc via Interaction with the NMDA Receptor
    15 T MAMIYA, T MATSUMURA, and M UKAI Ann. N.Y. Acad. Sci., Oct 2004; 1025: 424 - 429. Abstract
    Effects of L-745,870, a Dopamine D4 Receptor Antagonist, on Naloxone-Induced Morphine Dependence in Mice
    16 Norimasa Taniguchi, Shigeyuki Kanai, Masazumi Kawamoto, Hiroshi Endo, and Hideaki Higashino Evid. Based Complement. Altern. Med., Sep 2004; 1: 187 - 191. Abstract
    Study on Application of Static Magnetic Field for Adjuvant Arthritis Rats
    17 Takanori Akagi, Kazami Ushinohama, Shoko Ikesue, Eiji Yukawa, Shun Higuchi, Kenji Hamase, Kiyoshi Zaitsu, and Shigehiro Ohdo J. Pharmacol. Exp. Ther., Jan 2004; 308: 378. Abstract
    Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect
    18 Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta, Yukihiro Noda, and Toshitaka Nabeshima Mol. Pharmacol., May 2004; 65: 1293 - 1301. Abstract
    Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors
    19 K Shimosato and S Watanabe J Neurosci Methods, Sep 2003; 128(1-2): 103-10. Abstract
    Concurrent evaluation of locomotor response to novelty and propensity toward cocaine conditioned place preference in mice.
    20 Y Mikami, M Toda, M Watanabe, M Nakamura, Y Toyama, and Y Kawakami J Neurosurg, Jul 2002; 97(1 Suppl): 142-7. Abstract
    A simple and reliable behavioral analysis of locomotor function after spinal cord injury in mice. Technical note.
    21 Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Hisashi Mori, Masayoshi Mishina, and Toshitaka Nabeshima J. Neurosci., Mar 2002; 22: 2335. Abstract
    Lower Sensitivity to Stress and Altered Monoaminergic Neuronal Function in Mice Lacking the NMDA Receptor e4 Subunit
    22 Satoru Koyanagi and Shigehiro Ohdo Mol. Pharmacol., Dec 2002; 62: 1393. Abstract
    Alteration of Intrinsic Biological Rhythms during Interferon Treatment and Its Possible Mechanism
    23 Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Hisashi Mori, Masayoshi Mishina, and Toshitaka Nabeshima J. Neurosci., Jan 2001; 21: 750. Abstract
    Hyperfunction of Dopaminergic and Serotonergic Neuronal Systems in Mice Lacking the NMDA Receptor e1 Subunit
    24 Oliver Stork, Simone Stork, Hans-Christian Pape, and Kunihiko Obata Learn. Mem., Jul 2001; 8: 209 - 219. Abstract
    Identification of Genes Expressed in the Amygdala During the Formation of Fear Memory
    25 K Shimosato, S Watanabe, and S Kitayama Naunyn Schmiedebergs Arch Pharmacol, Jul 2001; 364(1): 74-80. Abstract
    Differential effects of trihexyphenidyl on place preference conditioning and locomotor stimulant activity of cocaine and methamphetamine.
    26 K Kobayashi, Y Noda, N Matsushita, K Nishii, H Sawada, T Nagatsu, D Nakahara, R Fukabori, Y Yasoshima, T Yamamoto, M Miura, M Kano, T Mamiya, Y Miyamoto, and T Nabeshima J. Neurosci., Mar 2000; 20: 2418. Abstract
    Modest Neuropsychological Deficits Caused by Reduced Noradrenaline Metabolism in Mice Heterozygous for a Mutated Tyrosine Hydroxylase Gene
    27 Mayumi Yamano, Hidenobu Yuki, Syuhei Yasuda, and Keiji Miyata J. Pharmacol. Exp. Ther., Jan 2000; 292: 181. Abstract
    Corticotropin-Releasing Hormone1 Receptors Mediate Consensus Interferon-a YM643-Induced Depression-Like Behavior in Mice
    28 K Shimosato and S Ohkuma Pharmacol Biochem Behav, Jun 2000; 66(2): 285-92. Abstract
    Simultaneous monitoring of conditioned place preference and locomotor sensitization following repeated administration of cocaine and methamphetamine.
    29 Y Oike, A Hata, T Mamiya, T Kaname, Y Noda, M Suzuki, H Yasue, T Nabeshima, K Araki, and K Yamamura Hum. Mol. Genet., Mar 1999; 8: 387 - 396. Abstract
    Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism
    30 Hiroko Ohki-Hamazaki, Yasushi Sakai, Katsuo Kamata, Hiroo Ogura, Shigeru Okuyama, Kei Watase, Kazuyuki Yamada, and Keiji Wada J. Neurosci., Feb 1999; 19: 948. Abstract
    Functional Properties of Two Bombesin-Like Peptide Receptors Revealed by the Analysis of Mice Lacking Neuromedin B Receptor
    31 Yukihiro Noda, Takayoshi Mamiya, Toshitaka Nabeshima, Miyuki Nishi, Masaya Higashioka, and Hiroshi Takeshima J. Biol. Chem., Jul 1998; 273: 18047. Abstract
    Loss of Antinociception Induced by Naloxone Benzoylhydrazone in Nociceptin Receptor-Knockout Mice
    32 Yukihiro Noda, Yoshiaki Miyamoto, Takayoshi Mamiya, Hiroyuki Kamei, Hiroshi Furukawa, and Toshitaka Nabeshima J. Pharmacol. Exp. Ther., Jul 1998; 286: 44. Abstract
    Involvement of Dopaminergic System in Phencyclidine-Induced Place Preference in Mice Pretreated with Phencyclidine Repeatedly
    33 Masayuki Hiramatsu, Hiroyasu Murasawa, Toshitaka Nabeshima, and Tsutomu Kameyama J. Pharmacol. Exp. Ther., Mar 1998; 284: 858. Abstract
    Effects of U-50,488H on Scopolamine-, Mecamylamine- and Dizocilpine-Induced Learning and Memory Impairment in Rats